Palladium‐Catalyzed Heck‐Type Cross‐Couplings of Unactivated Alkyl Iodides |
| |
| Authors: | Caitlin M. McMahon Prof. Erik J. Alexanian |
| |
| Affiliation: | Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (USA) |
| |
| Abstract: | A palladium‐catalyzed, intermolecular Heck‐type coupling of alkyl iodides and alkenes is described. This process is successful with a variety of primary and secondary unactivated alkyl iodides as reaction partners, including those with hydrogen atoms in the β position. The mild catalytic conditions enable intermolecular C? C bond formations with a diverse set of alkyl iodides and alkenes, including substrates containing base‐ or nucleophile‐sensitive functionality. |
| |
| Keywords: | alkenes alkyl halides cross‐coupling homogeneous catalysis palladium |
|
|
