Copper‐Catalyzed Electrophilic Amination of Heteroarenes and Arenes by CH Zincation |
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| Authors: | Stacey L McDonald Charles E Hendrick Prof?Dr Qiu Wang |
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| Affiliation: | Department of Chemistry, Duke University, Durham, NC 27708‐0346 (USA) |
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| Abstract: | Direct amination of heteroarenes and arenes has been achieved in a one‐pot C? H zincation/copper‐catalyzed electrophilic amination procedure. This amination method provides an efficient and rapid approach to access a diverse range of heteroaromatic and aromatic amines including those previously inaccessible using C? H amination methods. The mild reaction conditions and good functional‐group compatibility demonstrate its great potential for the synthesis of important and complex amines. |
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| Keywords: | amination C H functionalization copper heterocycles synthetic methods |
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