Abstract:Accumulation of fine particulate matter, such as lead, from food contact plastic products or automobile exhaust, is one of the most important risk factors for human health. The Pb-containing fine particulate matter was chose to study the biological transport and biodistribution after inhalation exposure in rats. After exposure, blood, urine, feces, important organs, and bones were collected regularly, of which Pb levels were tested by atomic absorption meter. Pb-containing fine particles, with 7.05 ± 0.83 μg/m³, entered the blood faster after inhalation exposure and accumulated in lung at a higher concentration (4.2 ± 0.67 μg/g), and which was significant difference compared with the oral administration group (P<0.01). Pb-containing fine particles were excreted mainly through urine at low excretion rate, and most of them were accumulated in rib and femur. We can draw that Pb-containing fine particulate matter increased lung exposure and accumulation in bone after inhalation exposure. The results demonstrated that Pb-containing fine particulate matter with more hazard exposure in inhalation.