高等学校化学学报

高等学校化学学报 ›› 2003, Vol. 24 ›› Issue (2): 249.

• 研究简报 • 上一篇    下一篇

桑色素及其配合物与DNA作用的研究

宋玉民, 康敬万, 卢小泉, 王志华, 高锦章   

  1. 西北师范大学化学化工学院, 兰州 730070
  • 收稿日期:2001-09-11 出版日期:2003-02-24 发布日期:2003-02-24
  • 通讯作者: 康敬万(1938年出生),男,教授,主要从事电分析化学研究.E-mail:jwkang@nwnu.edu.cn E-mail:jwkang@nwnu.edu.cn
  • 基金资助:

    西北师范大学科技创新工程和西北师范大学青年自然科学基金资助

Studies on the Interactions Between Morin and Its Cu(Ⅱ)-, Zn(Ⅱ)-Complexes with DNA

SONG Yu-Min, KANG Jing-Wan, LU Xiao-Quan, WANG Zhi-Hua, GAO Jin-Zhang   

  1. College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China
  • Received:2001-09-11 Online:2003-02-24 Published:2003-02-24

PDF (PC)

被引次数

86

关键词: 桑色素, 配合物, DNA, 作用方式, 荧光

Abstract: The interactions of Morin and its Cu(Ⅱ)-, Zn(Ⅱ)-complexes with calf thymus DNA have been studied by using fluorimetric and electrochemical methods. Cu(Ⅱ)-, Zn(Ⅱ)-complexes have different spectra and electrochemical characteristics from that of Morin in the presence of DNA. The results suggest that Morin and its complexes can both bind to DNA, but the binding mode is different. The complexes bind to DNA mainly like EB by intercalation, while Morin binds in a non-intercalating mode.

Key words: Morin, Complex, DNA, Binding mode, Fluorescence

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