| 碳量子点荧光猝灭法检测药物中的异鼠李素 |
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| 基金项目:山西省教育厅高等学校科技创新项目(2019L0750)；大同市重点研发计划项目基金( 2018014) |
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| 中文摘要:以L-天冬氨酸为碳源，尿素为氮源，采用微波加热法制备荧光碳量子点(CDs)，得到的CDs具有球形结构和单一分散性，平均粒径约为5 nm。红外光谱、X射线光电子能谱、紫外和荧光光谱的表征结果表明，合成的CDs具有较高的荧光稳定性，良好的水溶性和对异鼠李素(ISOR)高的选择性。在优化条件下，ISOR浓度在0.22~180 nmol/L范围内时与CDs荧光猝灭程度(IF0/IF)呈良好的线性关系，检出限(LOD)为1.32 nmol/L，回收率为90.8%~107%。结果表明，该CDs可用于ISOR的快速、高效、灵敏检测。 |
| 中文关键词:L-天冬氨酸 尿素 碳量子点 异鼠李素 猝灭 |
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| Facile Synthesis of Fluorescence Carbon Quantum Dots and Their Application in Detection of Isorhamnetin in Medicines |
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| Abstract:kind of novel fluorescence carbon quantum dots(CDs) were fabricated by microwave heating method using L aspartic acid and urea as the precursors.The obtained CDs exhibited good spherical shapes with an average size about 5 nm.In addition,the CDs were characterized by Fourier transform infared spectroscopy,X-ray photoelectron spectroscopy,ultraviolet-visible absorption spectroscopy and fluorescence spectroscopy.The CDs showed high fluorescence stability,good particle dispersion,excellent water solubility and remarkable selectivity toward isorhamnetin(ISOR).Under the optimized conditions,there was a good relationship between fluorescence quenched degree(IF0/IF) of the CDs and concentration of ISOR in the range of 0.22-180 nmol/L with a limit of detection(LOD) of 1.32 nmol/L.The CDs were successfully applied in the detection of ISOR in ginkgo biloba tablets with recoveries of 90.8%-107%.Results showed that the as synthesized CDs could be used in ISOR detection with rapidness,efficiency and sensitivity. |
| Key Words:L-aspartic acid urea carbon quantum dots(CDs) isorhamnetin quench |
| 引用本文：李海红，刘荔贞，冯锋.碳量子点荧光猝灭法检测药物中的异鼠李素[J].分析测试学报,2020,39(4):514-519. |
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