毛细管电泳技术在重大疾病特异性蛋白质分析中的应用

doi:10.3724/SP.J.1123.2011.00298

色谱 ›› 2011, Vol. 29 ›› Issue (04): 298-302.DOI: 10.3724/SP.J.1123.2011.00298

毛细管电泳技术在重大疾病特异性蛋白质分析中的应用

钱金雄, 杨秀娟, 陈缵光*

中山大学药学院, 广东广州 510006

收稿日期:2010-10-26 修回日期:2011-03-06 出版日期:2011-04-28 发布日期:2011-04-28
通讯作者: 陈缵光,博士,教授,博士生导师. E-mail: chenzg@mail.sysu.edu.cn.
基金资助:
国家自然科学基金项目(20727006)和广东省科技计划项目(2008A030102009).

Application of capillary electrophoresis in analysis of disease specific proteins

QIAN Jinxiong, YANG Xiujuan, CHEN Zuanguang*

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China

Received:2010-10-26 Revised:2011-03-06 Online:2011-04-28 Published:2011-04-28

摘要/Abstract

摘要： 人类重大疾病特异性蛋白质的识别、鉴定等是目前生命科学亟待解决的问题。毛细管电泳技术用于蛋白质分析,具有装置简单、分析速度快、试剂和样品消耗少以及有多种分离模式和检测手段等特点。本文综述了毛细管电泳技术在人类重大疾病特异性蛋白质分析中的应用,包括肿瘤疾病、神经退行性疾病和输血性传染病等的特异性蛋白质检测。

关键词: 蛋白质, 疾病, 毛细管电泳

Abstract: One of the most urgent things in life science is to find out special proteins related to human diseases. Capillary electrophoresis (CE) shows many advantages in protein analysis, such as high separation efficiency, high speed, low cost, etc. Furthermore, there are many different separation modes and multifarious detectors can be chosen in CE for the analysis of different samples. In this paper, the applications of CE in the analysis of specific proteins, which might associate with some serious diseases, such as tumor, neurodegenerative disease and transfusion transmitted infections, are summarized.

Key words: disease, protein, capillary electrophoresis （CE)

钱金雄, 杨秀娟, 陈缵光*. 毛细管电泳技术在重大疾病特异性蛋白质分析中的应用[J]. 色谱, 2011, 29(04): 298-302.

QIAN Jinxiong, YANG Xiujuan, CHEN Zuanguang*. Application of capillary electrophoresis in analysis of disease specific proteins[J]. Chinese Journal of Chromatography, 2011, 29(04): 298-302.

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毛细管电泳技术在重大疾病特异性蛋白质分析中的应用

Application of capillary electrophoresis in analysis of disease specific proteins

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