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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (9): 1616-1619. 上一篇    下一篇

研究简报

2-氨基-3-氰基-4-芳基-6-二茂铁基吡啶的合成

孙 晶 ; 张丽丽 ; 柳冬梅; 高 卉; 颜朝国*   

  1. (扬州大学化学化工学院 扬州 225002)
  • 收稿日期:2008-01-22 修回日期:2008-03-07 发布日期:2008-09-20
  • 通讯作者: 颜朝国

One-Pot Synthesis of 2-Amino-3-cyano-4-[(un)substituted phenyl]-6-ferrocenylpyridines

SUN, Jing; ZHANG, Li-Li;LIU, Dong-Mei;GAO, Hui;YAN, Chao-Guo*   

  1. (College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002)
  • Received:2008-01-22 Revised:2008-03-07 Published:2008-09-20
  • Contact: YAN, Chao-Guo

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1376

被引次数

3

以乙酰二茂铁、芳香醛、丙二腈为原料, 在乙酸铵存在下以乙醇为溶剂, 采用一锅煮的方法合成了8个2-氨基-3-氰基-4-芳基-6-二茂铁基吡啶化合物, 产率中等. 并通过X射线衍射分析确证产物4e的结构.

关键词: 吡啶, 多组分反应, 芳香醛, 一锅煮反应, 丙二腈, 二茂铁

One-pot multicomponent reactions of acetylferrocene, (un)substituted benzaldehyde and malononitrile in refluxing ethanol with ammonium acetate as a catalyst gave 2-amino-3-cyano-4- [(un)substituted phenyl]-6-ferrocenylpyridines in moderate yields. Eight ferrocenyl pyridine derivatives were prepared efficiently and one single crystal structure of 4e was determined.

Key words: multicomponent reaction, ferrocene, pyridine, malononitrile, benzaldehyde, one-pot reaction