| 三足配体汞(Hg)配合物的合成、结构及其与DNA相互作用的研究 |
| Synthesis, characterizationand interaction with native DNA of a tripodal ligand Hg(II) complex |
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| 摘要: 合成了基于邻羟基苯甲醛的三足配体Tris[(p-hydroxybenzaldehyde)ethyl]amine (L)，得到了该配体与汞的配合物，应用单晶X射线衍射技术测定了配体及其汞配合物的结构；应用用紫外吸收光谱、荧光光谱和粘度测定研究该配合物与小牛胸腺DNA 的作用。结果表明，该配合物与小牛胸腺DNA以插入的方式相结合。 |
| 关键词: 三足配体汞配合物 小牛胸腺DNA 插入作用 |
| 基金项目: “兰州大学中央高校基本科研业务费专项资金资助”项目编号：lzujbky-2013-194 |
| Abstract: Mercury(Ⅱ) Complex with Tris[(p-hydroxybenzaldehyde) ethyl]amine has been synthesized and characterized. The crystal and molecular structures of the complex was determined by singlecrystal X-ray diffraction. The interaction of complex with calf thymus DNA was investigated by UV-vis、 fluorescence spectrum and viscosity measurements. Results suggest that complex can bind to DNA via intercalation mode. |
| Keywords: CT-DNA tripodal ligand DNA-binding |
| 投稿时间：2012-11-05 修订日期：2013-07-04 |
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