首页 | 官方网站   微博 | 高级检索  
     

液晶态油酸脂质体与生物膜相互作用的理化特性
引用本文:张静,孙润广.液晶态油酸脂质体与生物膜相互作用的理化特性[J].物理学报,1994,43(9):1495-1501.
作者姓名:张静  孙润广
作者单位:(1)陕西师范大学实验中心; (2)陕西师范大学实验中心,中国科学院理论物理研究所
基金项目:北京市海淀区中关村分析测试基金资助的课题.
摘    要:用小角X射线散射用法和 31P核磁共振技术,对抗癌新药——液晶态油酸多相脂质体的结构进行了研究。实验结果表明:胆固醇、油酸、非离子表面活性剂均对PE脂质体液晶态的结构有显著的影响。在含有高效分散剂的磷酸盐缓冲溶液中制成的液晶态油酸多相脂质体由片层六角相和片层立方相组成。电子自旋共振研究表明,这种结构的脂质体与E腹水肝癌细胞相互作用的结果使W/S值增加。 关键词

关 键 词:抗癌药  油酸  脂质体  液晶态  NMR
收稿时间:1993-08-25

A STUDY OF THE PHYSICOCHEMICAL CHARACTER OF THE INTERACTION OF THE LIPOSOME CONTAINING OLEIC ACID OF THE LIQUID-CRYSTAL STATE AND BIOMEMBRANE
ZHANG JING and SUN RUN-GUANG.A STUDY OF THE PHYSICOCHEMICAL CHARACTER OF THE INTERACTION OF THE LIPOSOME CONTAINING OLEIC ACID OF THE LIQUID-CRYSTAL STATE AND BIOMEMBRANE[J].Acta Physica Sinica,1994,43(9):1495-1501.
Authors:ZHANG JING and SUN RUN-GUANG
Abstract:The structure of the liquid crystal state of the new antiturner agent, polyphase liposome containing oleic acid, has been studied by small angle puiypnase scattering (SAXS) and 31P nuclear magnetism resomance (31P-NMR). Experimental results show that the presence of cholesterol, oleic acid, nonionic surfactant will highly affect the structure of the liquid crystal state of the PE liposome containing oleic acid. The liquid crystal state of liposome with oleic acid made from phosphoric buffer solution containing polyvinylpyrrolidone consists of both lamellar-hexagonal phase and lamellar-cubic phase. Electron-spin-resonance (ESR) experiment shows that the W/S value in the Ehrlich ascites tumor cell increases as the amount of liposome increases.
Keywords:
本文献已被 CNKI 维普 等数据库收录!
点击此处可从《物理学报》浏览原始摘要信息
点击此处可从《物理学报》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司    京ICP备09084417号-23

京公网安备 11010802026262号