微波消解-ICP-MS法测定药用明胶空心胶囊中微量重金属元素

邱 丽; 施意华; 唐碧玉; 刘维理; 古行乾

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DOI:doi:10.3969/j.issn.2095-1035.2015.01.003

中国无机分析化学:2015,5(1):7-10

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微波消解-ICP-MS法测定药用明胶空心胶囊中微量重金属元素

邱丽¹, 施意华¹, 唐碧玉¹, 刘维理², 古行乾¹

(1.中国有色桂林矿产地质研究院有限公司测试中心，广西桂林 541004;2.桂林市食品药品检验所，广西桂林 541002)

Determination of Trace Heavy Metal Elements in Vacant Gelatin Capsules by ICP-MS after Microwave-Asisted Digestion

QIU Li¹, SHI Yihua¹, TANG Biyu¹, LIU Weili², GU Xingqian¹

(1.Testing Center,Guilin Research Institute of Geology and Mineral Resources,Guilin,Guangxi 541004,China;2.Guilin Institute for Food and Drug Control, Guilin,Guangxi 541004,China)

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本文已被：浏览 2596次下载 0次
投稿时间：2014-10-11 修订日期：2014-11-23

中文摘要: 采用微波消解试样技术，建立了一种电感耦合等离子体质谱法测定明胶空心胶囊中Cr，Co，Ni，Cu，Zn，As，Cd和Pb 9种微量重金属元素的方法。确定了微波消解仪和等离子体质谱仪的最佳操作参数，研究共存离子的干扰和消除方法，选择了各元素的测定同位素，以Ge，Rh和Tl为内标补偿基体效应，建立了样品测定方法。应用拟定的方法测定了不同生产厂家、不同批次的空心胶囊中微量重金属的含量。方法对试样中各元素测定的相对标准偏差范围为1.5%～14.1%，加标回收率在90.0%～102.0%。结果表明，方法简便、快速、灵敏，满足于空心胶囊中9种重金属元素的测定要求。

中文关键词: 空心胶囊微量元素电感耦合等离子体质谱法微波消解

Abstract:A method for the determination of the contents of 9 trace heavy metal elements (Cr，Co，Ni，Cu，Zn，As，Cd and Pb) in vacant gelatin capsules by inductively coupled plasma mass spectrometry (ICP-MS) after microware-assisted digestion was established. Analytical conditions for microwave digestion and ICP-MS instrumental operation were optimized. The interference from coexistent ions on determination of 9 elements and the interference eliminating methods were studied. 72Ge, 103Rh and 205Tl were chosen as internal standards to compensate matrix effects. By applying the proposed method, the contents of 9 trace heavy metal elements in vacant capsules from different factories and different batches were determined. The relative standard deviations (RSD) were in the range of 1.5%~14.1% with 90.0%~102.0% recoveries. The results indicate that the proposed method is simple, rapid and sensitive, and is suitable for the determination of the contents of 9 trace heavy metal elements in vacant capsules.

keywords: vacant gelatin capsules trace heavy metal elements ICP-MS microwave-assisted/digestion

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作者	单位
邱丽	中国有色桂林矿产地质研究院有限公司测试中心，广西桂林 541004
施意华	中国有色桂林矿产地质研究院有限公司测试中心，广西桂林 541004
唐碧玉	中国有色桂林矿产地质研究院有限公司测试中心，广西桂林 541004
刘维理	桂林市食品药品检验所，广西桂林 541002
古行乾	中国有色桂林矿产地质研究院有限公司测试中心，广西桂林 541004

引用文本：
邱丽,施意华,唐碧玉,刘维理,古行乾.微波消解-ICP-MS法测定药用明胶空心胶囊中微量重金属元素[J].中国无机分析化学,2015,5(1):7-10.
QIU Li,SHI Yihua,TANG Biyu,LIU Weili,GU Xingqian.Determination of Trace Heavy Metal Elements in Vacant Gelatin Capsules by ICP-MS after Microwave-Asisted Digestion[J].Chinese Journal of Inorganic Analytical Chemistry,2015,5(1):7-10.

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Author Name	Affiliation
QIU Li	Testing Center,Guilin Research Institute of Geology and Mineral Resources,Guilin,Guangxi 541004,China
SHI Yihua	Testing Center,Guilin Research Institute of Geology and Mineral Resources,Guilin,Guangxi 541004,China
TANG Biyu	Testing Center,Guilin Research Institute of Geology and Mineral Resources,Guilin,Guangxi 541004,China
LIU Weili	Guilin Institute for Food and Drug Control, Guilin,Guangxi 541004,China
GU Xingqian	Testing Center,Guilin Research Institute of Geology and Mineral Resources,Guilin,Guangxi 541004,China