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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (2): 311-316. 上一篇    下一篇

研究简报

新型1,5-二苯基-1,4-戊二烯-3-酮肟酯类化合物的合成及其抑菌活性研究

李少博，胡德禹，宋宝安*，杨松，金林红，薛伟
曾松，王俊，陈卓，卢平，周霞，樊玲娥   

  1. (贵州大学精细化工研究开发中心 教育部绿色农药与农业生物工程重点实验室 贵阳 550025)
  • 收稿日期:2007-02-10 修回日期:2007-05-25 发布日期:2008-02-01
  • 通讯作者: 宋宝安

Synthesis and Antifungal Activity of Novel 1,5-Diphenyl- 1,4-pentadien-3-one Oxime Esters

LI Shao-Bo,HU De-Yu,SONG Bao-An*,YANG Song,JIN Lin-Hong
XUE Wei,ZENG Song,WANG Jun,CHEN Zhuo, LU Ping
ZHOU Xia,FAN Ling-E   

  1. (Key Laboratory of Green Pesticide and Agricutural Bioengineering, Ministry of Education, Research and Development
    Center for Fine Chemicals, Guizhou University, Guiyang 550025)
  • Received:2007-02-10 Revised:2007-05-25 Published:2008-02-01
  • Contact: SONG Bao-An

PDF

1373

被引次数

57

以1,5-二苯基-1,4-戊二烯-3-酮肟和酰氯为原料, 合成了15个新型的1,5-二苯基-1,4-戊二烯-3-酮肟酯类化合物, 通过元素分析, IR, 1H NMR, 13C NMR等对其结构进行了表征. 初步生物活性试验结果表明, 在50 mg•L－1浓度下, 化合物3i和3o对小麦赤霉病菌抑制率分别为51.1%和 53.4%, 与对照药剂恶霉灵抑制活性相当.

关键词: 戊二烯酮, 肟酯, 合成, 抑菌活性

Fifteen 1,5-diphenyl-1,4-pentadien-3-one oxime esters were synthesized by the reaction of 1,5-diphenyl-1,4-pentadien-3-one oxmie with acyl chloride. Their structures were identified by elemental analysis, IR, 1H NMR and 13C NMR spectra. The preliminary bioassay showed that compounds 3i and 3o had certain antifungal activities against Fusarium graminearum with rate of 51.1% and 53.45% at a concentration of 50 mg•L－1 respectively, similarly to the control (hymexozole).

Key words: oxime ester, pentadienone, synthesis, antifungal activity